Product Name: CJC-1295 without DAC (Modified GRF 1-29) Quantity: 5mg (Lyophilized Powder) CAS Number: 863288-34-0

What is CJC-1295 without DAC?

CJC-1295 without DAC is the common name for a synthetic peptide that is chemically identical to Modified GRF (1-29). It is a 29-amino acid analogue of the endogenous Growth Hormone-Releasing Hormone (GHRH).

The “Modified” designation refers to four specific amino acid substitutions in its sequence relative to the original GRF (1-29). These substitutions (at positions 2, 8, 15, and 27) were engineered to protect the peptide chain from rapid enzymatic degradation, primarily by dipeptidyl peptidase-IV (DPP-IV). This modification significantly increases its stability and resistance in vivo compared to the native GHRH.

Mechanism of Action

As a GHRH analogue, Mod GRF (1-29) functions by binding to and activating GHRH receptors on the somatotroph cells of the anterior pituitary gland. This action signals the pituitary to synthesize and release endogenous growth hormone (GH).

Key Differentiator: “Without DAC”

The defining characteristic of this product is the absence of the Drug Affinity Complex (DAC).

• Short Half-Life: Without the DAC component (which extends peptide half-life by binding to albumin), CJC-1295 without DAC has a very short duration of action, with a half-life estimated at approximately 30 minutes.

• Pulsatile Release: This short half-life is favored in research settings aiming to mimic the natural, pulsatile (wave-like) secretion pattern of growth hormone, rather than the sustained, elevated “bleed” of GH associated with the DAC version.

Product Specifications

• Purity: >98% (as determined by HPLC)

• Appearance: Sterile, white lyophilized (freeze-dried) powder

• Storage: Store at 2°C to 8°C. For long-term storage, -20°C is recommended.

Disclaimer

This product is sold as 5mg of lyophilized powder in a sealed vial. It is intended strictly for laboratory and research use only. It is not for human consumption, therapeutic, or diagnostic use. Reconstitution with bacteriostatic or sterile water is required before research application.