Product Name: Epithalon (Epitalon)4

Quantity: 10mg (Lyophilized Powder)5

CAS Number: 307297-39-86

Overview

Epithalon is a synthetic tetrapeptide with the amino acid sequence Alanine-Glutamic acid-Aspartic acid-Glycine (Ala-Glu-Asp-Gly).⁷ It was developed as a synthetic version of Epithalamin, a polypeptide complex extracted from the pineal glands of animals.⁸

As a potent geroprotector, Epithalon is one of the most prominent peptides in longevity and anti-aging research.⁹ Its primary and most-studied mechanism of action is its ability to activate the enzyme telomerase.¹⁰

Mechanism and Research Interest

Epithalon is investigated for a variety of complex biological activities, all of which are subjects of advanced scientific study.¹¹

• Telomerase Activation: Epithalon is most famous for its potential to stimulate telomerase, an enzyme that adds repetitive DNA sequences to the ends of chromosomes (telomeres).¹² In normal cellular aging, telomeres shorten with each cell division, eventually leading to cell senescence (aging) and death.¹³ By activating telomerase, Epithalon is researched for its ability to lengthen telomeres, thereby protecting DNA from damage, increasing cellular lifespan, and counteracting cellular aging.¹⁴

• Pineal Gland Regulation: As an analogue of a pineal extract, Epithalon is studied for its ability to modulate the function of the pineal gland.¹⁵ This includes its potential to restore and normalize the circadian rhythm of melatonin production, which is often disrupted with age and can impact sleep quality and overall hormonal balance.¹⁶

• Antioxidant Effects: Research also explores Epithalon’s role in upregulating endogenous antioxidant enzymes and its “stress-protective” properties, potentially mitigating the damaging effects of oxidative stress on a cellular level.¹⁷

Product Specifications

• Purity: >98% (as determined by HPLC)¹⁸

• Appearance: Sterile, white lyophilized (freeze-dried) powder¹⁹

• Molecular Formula: ²⁰$C_{14}H_{22}N_{4}O_{9}$

• Molecular Weight: 390.35 g/mol²¹

• Storage: Store at 2°C to 8°C. For long-term storage, -20°C is recommended.²²

Disclaimer

This product is supplied as 10mg of sterile, lyophilized powder in a sealed vial. It is intended strictly for laboratory and research use only. It is not for human consumption, therapeutic, or diagnostic applications. Reconstitution with a suitable solvent (such as bacteriostatic water) is required before use.