MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring peptide encoded within the mitochondrial genome. Unlike most peptides, which are encoded in the cell’s nucleus, MOTS-c originates in the mitochondria and functions as a signaling molecule, playing a crucial role in mitochondrial-nuclear communication, especially in response to metabolic stress.

This 10mg product provides high-purity, lyophilized (freeze-dried) MOTS-c peptide for research purposes.

Key Characteristics and Areas of Research:

• Metabolic Regulation: MOTS-c is recognized as a powerful metabolic regulator. It is known to activate the AMP-activated protein kinase (AMPK) pathway, a master switch for cellular energy homeostasis.

• Insulin Sensitivity: Research suggests MOTS-c enhances glucose metabolism and improves insulin sensitivity, making it a significant subject in studies related to type 2 diabetes and metabolic dysfunction.

• Energy Homeostasis: By activating AMPK, MOTS-c helps promote cellular glucose uptake and fatty acid oxidation (the burning of fat for energy).

• Exercise and Aging: MOTS-c levels are shown to increase during exercise. It is often studied as an “exercise-mimetic” for its potential to mimic the metabolic benefits of physical activity. Its role in cellular health and mitochondrial function also makes it a target of anti-aging and longevity research.

• Inflammation: Preliminary studies indicate that MOTS-c may have anti-inflammatory properties and could play a role in mitigating inflammatory pain.

Product Details:

• Product Name: MOTS-C

• Quantity: 10mg

• CAS Number: 1627580-64-6

• Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

• Appearance: White lyophilized powder

• Storage: Store in a cool, dry place. For long-term storage, it is recommended to keep at -20°C. Once reconstituted, store at 2-8°C.

Disclaimer: This product is sold for Research Use Only (RUO). It is not intended for human consumption, diagnostic, or therapeutic purposes.