IGF-1 LR3 (Long Arginine 3 Insulin-like Growth Factor 1) is a synthetic, 83-amino acid analog of human IGF-1. This product provides 1mg of high-purity, lyophilized (freeze-dried) powder intended strictly for laboratory and research use.

The primary modifications—the substitution of an Arginine (R) for a Glutamic Acid (E) at the third position and a 13-amino acid extension at the N-terminus—are specifically engineered to enhance its biological properties.

Key Features:

• Enhanced Potency: The LR3 modification dramatically reduces the peptide’s affinity for Insulin-like Growth Factor Binding Proteins (IGFBPs).

• Extended Half-Life: By evading sequestration by IGFBPs, which normally neutralize standard IGF-1, the LR3 version remains biologically active for a much longer period (a half-life of 20-30 hours vs. ~20 minutes for native IGF-1).

• Increased Bioactivity: With more “free” peptide available to interact with the IGF-1 receptor (IGF-1R), IGF-1 LR3 is significantly more potent at stimulating cellular responses.

Research Applications:

In a research setting, IGF-1 LR3 is a powerful tool used to study the signaling pathways involved in growth and development. It is widely used in vitro to potently stimulate hyperplasia (an increase in the number of cells) and mitogenesis (cell division) in various cell lines, most notably in muscle myoblasts, connective tissue, and neural cells. Its stability and potency make it a preferred standard for research into tissue repair, cellular aging, and anabolic metabolic processes.

Product Specifications:

• Product Name: IGF-1 LR3

• Quantity: 1mg

• Appearance: Sterile, lyophilized white powder

• CAS Number: 946870-92-4

• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

• Molar Mass: 9117.5 g/mol

• Purity: Typically ≥98% (as determined by HPLC)

• Storage: Must be stored in a freezer (≤ -20°C) in its lyophilized state. After reconstitution with sterile, deionized water, store at 4°C and use within a short timeframe.

For Research Use Only: This product is sold for in vitro laboratory research purposes only. It is not intended for human or veterinary diagnostic or therapeutic use. It should be handled only by qualified, trained professionals in a laboratory setting.