Product Name: Melanotan 1

Alternative Names: Afamelanotide, [Nle4, D-Phe7]-α-MSH4

Catalog Number: [Enter SKU Here]

Batch No.: [Enter Batch No. Here]

Form: Lyophilized (freeze-dried) powder in a sterile vial5

Quantity: 10 mg6

CAS Number: 75921-69-67

What is Melanotan 1?

Melanotan 1, also known as Afamelanotide, is a synthetic peptide and a structural analog of the natural alpha-melanocyte-stimulating hormone (α-MSH). It is a linear peptide composed of 13 amino acids with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2.

This modification of the natural α-MSH structure, specifically the substitution with Norleucine (Nle) at position 4 and D-Phenylalanine (D-Phe) at position 7, grants it greater metabolic stability and a longer biological half-life.

Mechanism of Action

Melanotan 1 functions as a potent, non-selective agonist for the melanocortin receptors (MCRs), with a particularly strong binding affinity for the MC1R (Melanocortin 1 Receptor). Activation of the MC1R on melanocytes initiates a signaling cascade that stimulates melanogenesis—the process of producing melanin (pigment). This action results in increased skin pigmentation, which is the subject of research for its potential photoprotective effects against UV radiation.

Technical Specifications

• Molecular Formula: $C_{78}H_{111}N_{21}O_{19}$

• Molecular Weight: 1646.85 g/mol

• Purity (HPLC): ≥98%

• Appearance: White lyophilized powder

• Solubility: Soluble in bacteriostatic water or sterile water. Reconstitution is required before use.

Storage and Handling

• Before Reconstitution: Store lyophilized vials at -20°C (freezer) for long-term storage or at 2°C to 8°C (refrigerator) for short-term storage. Protect from light.

• After Reconstitution: Once reconstituted, the solution should be stored at 2°C to 8°C and used within a short timeframe. Avoid repeated freeze-thaw cycles.

For Research Use Only: This product is sold for in-vitro laboratory and research purposes only. It is not intended for human consumption, injection, or diagnostic/therapeutic use. It is the responsibility of the researcher to handle the product in accordance with established laboratory safety protocols.