CAS Number: 80714-61-0

SEMAX is a research peptide and nootropic agent originally developed in Russia, where it is classified as a vital and essential drug. It is a synthetic analog of a fragment of the adrenocorticotropic hormone (ACTH), specifically ACTH (4-10), modified with a Pro-Gly-Pro sequence at the C-terminus to increase its stability and biological activity.

Unlike ACTH, SEMAX is devoid of hormonal activity. Its primary effects are nootropic (cognitive-enhancing) and neuroprotective. Research indicates that SEMAX works through multiple mechanisms:

• Neurotrophic Factor Modulation: It is believed to significantly increase the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the brain. These proteins are crucial for neuronal survival, growth, and plasticity, which are the foundations of learning and memory.

• Neurotransmitter System Support: SEMAX may modulate the dopaminergic and serotonergic systems, which are key to regulating mood, motivation, and attention.

• Neuroprotection: The peptide has demonstrated protective effects against neuronal damage caused by hypoxia (oxygen deprivation), oxidative stress, and other neurotoxic events.

  In clinical settings where it is approved, SEMAX is used to treat conditions such as stroke, transient ischemic attack, cognitive disorders, and optic nerve disease. As a nootropic, it is researched for its potential to enhance attention, improve memory consolidation, and increase resilience to mental stress and fatigue.

Disclaimer: This product is intended for research purposes only. It is not for human or veterinary use. All information provided is for educational and informational purposes.