SS-31, also known as Bendavia or MTP-131, is a synthetic, cell-permeable aromatic-cationic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH2. Its unique structure allows it to freely cross cell membranes and selectively accumulate within mitochondria, independent of the mitochondrial membrane potential.

The primary mechanism of SS-31 involves its interaction with cardiolipin, a phospholipid exclusively found on the inner mitochondrial membrane. By binding to cardiolipin, SS-31 acts as a powerful antioxidant, scavenging harmful reactive oxygen species (ROS) like hydrogen peroxide and hydroxyl radicals directly at their source.

This targeted action protects mitochondrial integrity, enhances ATP (energy) production, and inhibits the opening of the mitochondrial permeability transition pore (mPTP). By preventing mPTP opening, SS-31 effectively blocks a key pathway to apoptosis (programmed cell death) and cellular damage.

Due to its unique ability to restore mitochondrial function and combat oxidative stress, SS-31 is a subject of extensive research for its potential therapeutic benefits in a wide range of age-related and metabolic conditions, including ischemia-reperfusion injury, cardiovascular disease, neurodegenerative disorders, and kidney disease.

• CAS Number: 779646-64-5

• Sequence: H-D-Arg-Dmt-Lys-Phe-NH2

• Synonyms: Bendavia, MTP-131

Disclaimer: This product is intended for research and laboratory use only. It is not approved for human or veterinary use and should not be used for diagnostic or therapeutic purposes.