SS31 (Elamipretide) – 50mg

CAS Number: 736992-21-5 (free base)

Formula: C₃₂H₄₉N₉O₅

Molecular Weight: 639.8 g/mol

Synonyms: Elamipretide, MTP-131

SS31, also known as Elamipretide, is a novel, cell-penetrating aromatic-cationic peptide at the forefront of mitochondrial research. Unlike most peptides that interact with surface receptors, SS31 is designed to target the primary source of cellular energy: the mitochondrion.

Its mechanism of action centers on its high affinity for cardiolipin, an exclusive phospholipid of the inner mitochondrial membrane. In conditions of high oxidative stress, cardiolipin is susceptible to damage, which destabilizes mitochondrial structure and impairs the electron transport chain (ETC), leading to reduced ATP (energy) production and a cascade of further oxidative damage.

SS31 selectively binds to cardiolipin, acting like a molecular chaperone to protect it from oxidative degradation. By stabilizing the cardiolipin-ETC interface, SS31 is reported to help restore the efficiency of oxidative phosphorylation, enhance ATP synthesis, and decrease the production of reactive oxygen species (ROS).

Due to its fundamental role in cellular energy and protection, SS31 is a subject of extensive research in numerous areas, including:

• Cardiovascular diseases (e.g., heart failure)

• Neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s)

• Ischemia-reperfusion injury (e.g., stroke and heart attack)

• Age-related cellular decline and sarcopenia

• Metabolic and kidney disorders

This product is provided as a 50mg quantity of lyophilized powder, intended strictly for laboratory and research purposes. It is not for human consumption or diagnostic use.