Vasoactive Intestinal Peptide (VIP) is a biologically active neuropeptide predominantly found in the central and peripheral nervous systems, as well as the gastrointestinal tract. Composed of 28 amino acids, it functions by binding to the VPAC1 and VPAC2 receptors, which in turn activates adenylyl cyclase and increases intracellular cAMP levels.

As a powerful vasodilator, VIP plays a crucial role in regulating blood flow, blood pressure, and smooth muscle relaxation in various tissues, including the trachea and gut. Beyond its circulatory effects, VIP is a significant modulator of the immune system, known to promote an anti-inflammatory profile by regulating cytokine production.

In research settings, VIP is extensively studied for its pleiotropic effects. Key areas of investigation include:

• Gastrointestinal Function: Studying its role in stimulating intestinal water and electrolyte secretion while inhibiting gastric acid.

• Neuroprotection: Investigating its potential to protect neurons from inflammatory and oxidative stress.

• Inflammatory Conditions: Examining its therapeutic potential in models of inflammatory bowel disease (IBD), rheumatoid arthritis, and pulmonary fibrosis.

• Circadian Rhythms: VIP is essential for the function of the suprachiasmatic nucleus (SCN), the body’s primary pacemaker, making it vital for circadian rhythm research.

CAS Number: 40077-57-4

Molecular Formula: C₁₄₇H₂₃₈N₄₄O₄₂S

Appearance: White Lyophilized Solid

Disclaimer: This product is sold in a 5mg vial and is intended for laboratory research use only. It is not for human consumption, diagnostic, or therapeutic purposes.